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The main adverse reactions in group PLD were hand foot syndrome and myelosuppression. The main adverse reactions in group G/O were gastrointestinal reaction and myelosuppression. The incidence rates of leucocyte reduction (65.0% vs. 92.5%, (2=9.04, P=0.003), thrombopenia (15.0% vs. 52.5%, (2=12.58, P0.001), anemia (15.0% vs. 40.0%, (2=6.27, P=0.012), gastrointestinal reaction (17.5% vs. 60.0%, (2=15.22, P0.001) and neurotoxicity (5.0% vs. 30.0%, (2=8.66, P=0.003) in group PLD were lower than those in group G/O. The total incidence of adverse reactions in group PLD was lower than that in group G/O, with significant difference. Conclusion The efficacy of two chemotherapy regimens is similar in patients with recurrent platinum-resistant ovarian cancer. 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