血管生成与骨肉瘤的相关性研究进展

doi:10.3760/cma.j.cn371439-20241224-00029

摘要/Abstract

摘要：

骨肉瘤是一类间质组织肿瘤，具有高侵袭性和转移性。促血管生成因子、血管内皮细胞在骨肉瘤血管生成和转移中起关键作用，血管内皮细胞与骨肉瘤细胞的相互作用可影响骨肉瘤的生长及转移，骨肉瘤抗血管治疗药物包括单克隆抗体、酪氨酸激酶抑制剂、中药等均可抑制骨肉瘤的进展。深入研究血管生成与骨肉瘤的相关性，可为骨肉瘤血管化研究及骨肉瘤抗血管治疗提供新的思路。

关键词: 骨肉瘤, 血管生成诱导剂, 内皮细胞

Abstract:

Osteosarcoma is a kind of mesenchymal tissue tumor，which is highly invasive and metastatic. Pro-angiogenic factors and vascular endothelial cells play key roles in the angiogenesis and metastasis of osteosarcoma，and the interaction between vascular endothelial cells and osteosarcoma cells can affect the growth and metastasis of osteosarcoma. Anti-vascular therapeutics agents for osteosarcoma，including monoclonal antibodies，tyrosine kinase inhibitors and traditional Chinese medicines，can inhibit the progression of osteosarcoma. An in-depth study of the correlation between osteosarcoma and angiogenesis can provide new ideas for the study of vascularization of osteosarcoma and anti-vascular treatment of osteosarcoma.

Key words: Osteosarcoma, Angiogenesis inducing agents, Endothelial cells

蒲文霞, 邓宗卓, 王培鑫, 王秋兰. 血管生成与骨肉瘤的相关性研究进展[J]. 国际肿瘤学杂志, 2025, 52(3): 186-189.

Pu Wenxia, Deng Zongzhuo, Wang Peixin, Wang Qiulan. Research progress of the correlation between angiogenesis and osteosarcoma[J]. Journal of International Oncology, 2025, 52(3): 186-189.

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